Kike is a slur used to describe Jews in a derogatory way. Originates from the word 'keikl', in Yiddish, which means 'circle', the reason being that the first Jewish immigrants in America, who were unable to sign their names, signed with a circle instead of a cross.
The word Kike is a racial slur that has been used historically to degrade and dehumanize jews. The word is still used by some people for this purpose, and it is seen as offensive and hurtful to jews. If you are unsure about whether or not it is appropriate to use the word Kike, it is best to err on the side of caution and avoid using it in any situation.