Guachupine is a slur used to describe Spaniards in a derogatory way. Used in Mexico as reference to disease bringing Spaniards who brought a plague called guachu to the natives when the conquistadores conquered Mexico.
The word Guachupine is a racial slur that has been used historically to degrade and dehumanize spaniards. The word is still used by some people for this purpose, and it is seen as offensive and hurtful to spaniards. If you are unsure about whether or not it is appropriate to use the word Guachupine, it is best to err on the side of caution and avoid using it in any situation.