You People is a slur used to describe Blacks in a derogatory way. Ross Perot, while at the 1992 NAACP convention in Nashville TN, frequently addressed his audience as "you people." Revitalized again in April, 2007 when Don Imus said "I can't get any place with you people" on the Rev. Al Sharpton's radio show.
The word You People is a racial slur that has been used historically to degrade and dehumanize blacks. The word is still used by some people for this purpose, and it is seen as offensive and hurtful to blacks. If you are unsure about whether or not it is appropriate to use the word You People, it is best to err on the side of caution and avoid using it in any situation.